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Caffeine stimulates lipolysis, following the increase in cAMP, increasing the availability of free fatty acids that are then oxidized for energy without significantly altering carbohydrate metabolism, although a glycogen-sparing effect has been observed [76]

Liu Y, Song R, Zhao L, Lu Z, Li Y, Zhan X, et al

Glutathione levels in the body may be reduced by a number of factors, including poor nutrition, environmental toxins and stress

doi: 10.3382/ps.0571260

Together they can target appetite from two angles (gastric emptying + central satiety), a frequent rationale behind blend designs

Understanding Glutathione Glutathione is often called the "master antioxidant" because your body makes it naturally in your liver