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Fatigue has been reported with tirzepatide use, though the exact frequency may vary from other GLP-1 agonists

Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, doubleblind, placebo and active controlled, doseranging, phase 2 trial

Bravo, J

Ritzel R, Maubach J, Bsing M, Becker T, Klempnauer J, Hcking K, Schmiegel WH, Nauck MA

[1] MB can interfere with microbial DNA and replication, and in the case of malaria parasites (Plasmodium species), it inhibits their glutathione reductase and other enzymes, enhancing the efficacy of other antimalarial drugs and contributing to parasite clearance

These changes do not happen identically in every woman, but they are common enough to shape how medications are experienced