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NICE technology appraisal guidance (TA875) supports its use in specialist weight management services in England, subject to eligibility criteria and local availability Tirzepatide (Mounjaro) approved by the MHRA for type 2 diabetes and, more recently, for weight management

Although Semaglutide has its challenges, it remains a valuable medication for many patients

Steady-state concentrations are achieved after approximately 4 weeks of maintaining a consistent dose, at which point the full therapeutic effect becomes apparent

Semaglutide does not preferentially target visceral abdominal fat, but clinical trials demonstrate significant reductions in both visceral and subcutaneous abdominal adiposity as part of overall fat loss

The absence of metabolic disruption deserves emphasis

Practically inadvisable