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49 Selective serotonin reuptake inhibitors (SSRIs), a class of antidepressants that have been proven to successfully treat clinical depression, were developed in response to this hypothesis, which was derived primarily on the basis of the pharmacological mechanism of drug that were accidentally discovered to act as antidepressants

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Clinicians should consider checking serum bicarbonate at baseline and periodically during treatment, particularly in patients with renal impairment, those following a ketogenic diet, or those taking other carbonic anhydrase inhibitors

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Jiang K, Tang K, Liu H, Xu H, Ye Z, Chen Z