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Titration Start tirzepatide alone for 8 weeks, then add cagrilintide at 0.25 mg/week

Lipodystrophy, scar tissue buildup, and chronic injection site reactions are all consequences of poor rotation

In a 68-week clinical study of Wegovy, about 1 in 3 adults with obesity or with overweight and weight-related medical problems achieved 20% weight loss

Although these two drugs were originally developed to improve glycemic control in people with type 2 diabetes, they simultaneously cause significant weight loss in these patients, without too many major side effects, and could therefore represent a new therapeutic strategy for the normalization of body weight

It also mimics glucose-dependent insulinotropic polypeptide (GIP), another hormone involved in insulin secretion

The most common adverse events were mild-to-moderate headaches, similar in frequency to placebo groups