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Together, they produce a more comprehensive metabolic response than either pathway alone

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In pivotal SURMOUNT-1 data, tirzepatide produced a 20.9% mean weight reduction, outperforming semaglutides 14.9% STEP-1 result

Zhao M, Zhao L, Xiong X, He Y, Huang W, Liu Z, Ji L, Pan B, Guo X, Wang L, Cheng S, Xu M, Yang H, Yin Y, Garcia-Barrio MT, Chen YE, Meng X, Zheng L (2020) TMAVA, a metabolite of intestinal microbes, is increased in plasma from patients with liver steatosis, inhibits gamma-butyrobetaine hydroxylase, and exacerbates fatty liver in mice

Your provider will review your health history to ensure the new medication is appropriate for you