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The anterior pituitary becomes accustomed to amplified signaling, and when that signal vanishes, there's a lag period of 10-21 days before endogenous pulse patterns normalize

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In Panel A, one can see that the 15 g dose has a relatively small effect on the percentage of surviving hepatocytes in females, descending only from 1 to 0.9

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a second group of 20 women received a placebo