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[4] [5] Additional contributing factors include: Sleep disturbances and night sweats disrupting metabolic regulation Reduced physical activity due to fatigue or joint discomfort Psychological factors including stress, mood changes, and emotional eating Changes in insulin sensitivity Weight changes during the menopausal transition vary considerably between individuals

452 COX2 is an essential molecular basis for cancer progression, which promotes the proliferation and invasive ability of tumors and inhibits cancer cell apoptosis

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Vitamin B-12 also plays a role in the synthesis of neurotransmitters