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Tirzepatide-based evidence from the SURPASS (Researching Tirzepatide in Patients with Type 2 Diabetes for Glycemic Control and Weight Management) trials (SURPASS-1 NCT03954834 and SURPASS-5 NCT04039503) demonstrated dose-dependent, significant weight loss over 40 weeks compared with placebo, along with reductions in BMI and waist circumference [62, 63]

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The most commonly prescribed options include GLP-1 receptor agonists such as semaglutide (Wegovy) and liraglutide (Saxenda), which are FDA-approved specifically for chronic weight management

Its important for patients to be educated about recognizing the signs of hypoglycemia and how to manage it, including having quick access to a source of glucose

Patients who have palpitations with no arrhythmia causality and no cardiac disease should be reassured