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Clinical trials used doses up to 16mg loading followed by 16mg maintenance every 23 months, but research protocols typically use lower daily dosing for gradual melanogenesis induction

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Statistical analysis All outcomes except body mass were analyzed using two-way analysis of variance (ANOVA) with group and age specified as between-subjects factors

Jacob JM, Ferry EK, Gay LM, Elvin JA, Vergilio JA, Ramkissoon S, et al

FDA prescribing information for these medications includes warnings about the risk of acute kidney injury in patients who experience severe adverse gastrointestinal reactions