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For instance, senescent M1 macrophages within atherosclerotic plaques release SASPs, increasing oxidative stress levels within plaques, leading to instability, rupture, and a heightened risk of AF (Vellasamy et al., 2022)

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By signaling through GLP-1R expressed in the reward and satiety areas of central nervous system, GLP-1RAs reduce caloric intake and result in 14 kg weight loss on average over several months

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