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GTP-bound RAS (activated form) binds to RAF proteins (c-RAF, BRAF, and ARAF) and induces conformational alternations to dimerize RAF, which is activated and turns on the kinase cascade [110]

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8:e5077710.7554/eLife.50777 Elife Summary Keywords glutathione peroxidase 1, spiral ganglion neuron, peroxynitrite, oxidative stress, nuclear factor-kappa B, hearing loss Citation Wang X, Han Y, Chen F, Wang M, Xiao Y, Wang H, Xu L and Liu W (2022) Glutathione Peroxidase 1 Protects Against Peroxynitrite-Induced Spiral Ganglion Neuron Damage Through Attenuating NF-B Pathway Activation

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