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High proline content (three consecutive prolines at positions 3-5) introduces conformational constraints

If this condition persists, it can interfere with tendon healing resulting in chronic tendon thickening known as common flexor tendinopathy, commonly referred to as Golfers elbow

Side effects are typically mild and may include redness or swelling at the injection site, headaches, or digestive discomfort

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Reported side effects are generally mild but can include injection site reactions, transient fatigue, and headache

doi: 10.1124/pr.113.007724 113 TalbotJBianchiniFJNascimentoDCOliveiraRDSoutoFOPintoLGet al