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Oba J, Nakahara T, Abe T, Hagihara A, Moroi Y, Furue M

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17 Consequently, the elevated histone Kla upregulates pluripotent genes such as Oct4, Sall4, and Mycn and promotes somatic cell reprogramming and pluripotency, revealing a glycolysis-driven signaling cascade linking the epigenome and metabolome in cell-fate determination

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6 Limitation and future research priorities Despite the promising potential of ferroptosis-targeting therapies, several limitations currently hinder their translation into clinical practice