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While specific therapies for IBM are still lacking, NAD + boosters have shown promising results in various models, including nematodes with amyloid aggregation, aged rodents, and human muscle cells from IBM patients
Complementary supplements, such as 400 IU of vitamin E, 500 mg of vitamin C, and 20-40 mg of zinc, further support cellular function and protect against oxidative stress
Furthermore, H&E staining showed that compared to the aorta of normal aging mice, the aorta of mice treated with FOXO4-DRI was thinner, and the PWV value was lower in the ultrasound detection results, which means that the mice treated with FOXO4-DRI had better vascular elasticity and better vascular function than normal aging mice (Figures 1D,E)
Studies have observed that female mice exposed to DSIP for 5 consecutive days of every month starting at the age of 3 months till their death exhibited a 2.6-fold reduction in the development of tumors compared to parallel control groups
This pairing has shown average weight loss of over 20% in research, which puts it in the same range as Retatrutide used alone
