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Consistent with the nuclear action of Lani, most proteins downregulated by GLP-1GIPLani (cluster 1) were associated with nuclear processes such as RNA processing, neurotransmitter receptor internalization and chromosome organization, whereas proteins upregulated by GLP-1GIPLani were mainly linked to neurotransmitter receptor internalization (Fig

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Increased lipogenesis and fatty acid reesterification contribute to hepatic triacylglycerol stores in hyperlipidemic Txnip -/- mice