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In the context of prolonged systemic administration, NMDA receptor antagonists, such as memantine and MK-801 (also known as dizocilpine), induce anorexia and weight loss in rodents 9,10,11

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During your first 23 months on semaglutide, keep a symptom diary noting any abdominal cramping, bloating, or constipation beyond normal GLP-1 side effects

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There is no formal definition, but in the athlete community, microdosing typically means staying at or below 0.5mg weekly semaglutide rather than titrating up to the standard 1.7mg or 2.4mg therapeutic doses

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