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ZIP7 also plays a protective role in ER homeostasis because its inhibition triggers ER stress, making it functionally linked to ER-associated degradation (ERAD) and stress mitigation 70

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Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells

Light exposure represents a significant degradation pathway, with UV and visible light catalyzing oxidative damage to the peptide backbone and disruption of copper coordination

H., Meyerson, M., Richardson, A