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Moreno-Madrid I, Romero-Imbroda J, Reyes-Bueno JA et al (2025) Peripheral expression of NPY1R-based heteroreceptor complexes reflects hippocampal neuroimmune status: novel biomarkers for early Alzheimers disease detection

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Glutamate accumulation to micromolar levels [375] results in GluN2B-mediated NMDA receptor overactivation, Ca 2+ overload, and subsequent tau hyperphosphorylation and dendritic spine collapse [376], linking excitotoxicity to amyloidogenesis [28]