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Any energy improvements result from indirect effects such as better blood sugar control, weight loss, and improved overall metabolic health rather than central nervous system stimulation

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Therefore, significant molecular changes during the pre-symptomatic phase caused by TrkB signalling depletion may induce iSPN vulnerability

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Source: New England Journal of Medicine, STEP 1 trial (2021) Weight loss by week (avg.) Typical patient trajectory Individual results vary

Examples of foods rich in soluble fibre include oats, beans and legumes, fruits like apricots, oranges and mangoes, vegetables like broccoli and Brussels sprouts