Glutathione functions as a key regulator of redox homeostasis, directly neutralizing reactive oxygen species and free radicals, thereby protecting cells from oxidative damage
[5] Uniquely, ALA is often termed a universal antioxidant because it is soluble in both water and lipid environments, and it has the ability to regenerate other antioxidants such as vitamin C, vitamin E, and glutathione from their oxidized forms
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Our model suggests that the large male-female differences in GSH concentration and the velocity of its synthesis cause females to be less sensitive to APAP toxicity compared to males
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