A landmark study published in JAMA Psychiatry in 2025 showed that semaglutide significantly reduced alcohol consumption in people with alcohol use disorder
The nitric oxide connection is relevant because improved blood flow and vascular function support nutrient delivery, exercise performance, and metabolic function
However, the plaintiff alleges that merely increasing the amount of GLP-1 in the body does not help achieve weight loss, because GLP-1 has such a short half-life at only about two minutes. Despite ongoing litigation, Waldstein noted that only one company to date has received an FDA warning letter for making false and misleading claims related to semaglutide, comparing its GLP-1 support supplement to the drug
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In other studies, it has been shown that dual GLP-1/GIPR agonists exert neuroprotective effects in animal models of AD and PD (83, 172)
It also slows gastric emptying significantly, which means food moves out of your stomach more slowly, keeping you feeling full longer and blunting post-meal blood sugar spikes