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Quast, D., Schenker, N., Menge, B., Nauck, M., Kapitza, C., Meier, J

More seriousbut rareside effects include pancreatitis, kidney problems, low blood sugar (hypoglycemia), or allergic reactions

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Long-term metformin use and vitamin B12 deficiency in the Diabetes Prevention Program Outcomes Study

In future trials it will be important to keep track of comorbidities for clinical trial design, either for the purpose of post hoc subgroup analysis or a priori subgroup recruitment, since the neuroathophysiological mechanisms in IC/ BPS patients with different co-morbidities are likely to be different