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Exceptional safety margin No dependence or tolerance naturally occurring endogenous peptide Tolerability in clinical trials No tolerance develops with repeated doses No withdrawal symptoms upon stopping Peptide naturally present in the human body Research considerations Researcher's notes Outstanding safety profile for a bioactive peptide No serious adverse events were reported in the published studies

Kumar S, Xu J, Perkins C, Guo F, Snapper S, Finkelman FD, et al

The result is that improvements in gut symptom burden, mucosal integrity, and post-meal function often begin within the first 7 to 14 days of the protocol

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44 (Supplement_1): S4S6