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Similarly, for the RW subacute toxicity study, an increase in sodium and potassium levels were observed in the 1,000 mg/kg mice, which indicates possible kidney and/or heart dysfunction

102,227,228,314,315,316,317 These effects lead to arterial resistance and remodeling, ultimately contributing to renal dysfunction and fibrosis

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J Neurosci 21 : 68976904

Acknowledgements This study was supported by the National Natural Science Foundation of China (81871790) & (81572167) and the Shanghai Hospital Development Center Foundation (SHDC12016110)