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In a larger RCT with 269 participants, NAC (2 g/day) showed a slight but remarkable increase in MADRS ratings at over 16 weeks of monitoring when compared to a placebo

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And, of course, this is all provided for information purposes only (in case you get asked about this on Jeopardy) and again, always speak with your medical doctor before starting anything new: Dosage : A common starting dose for DSIP is between 100 and 200 mcg per administration, with some individuals titrating up to 400 mcg or more depending on their response and tolerance