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Both arms had appropriate dose escalation to usual max dosages as once-weekly SubQ injections for 16 months resulting in an average of 20% weight loss for tirzepatide and 14% for semaglutide

Most Cochrane systematic reviews and protocols did not adhere to the Cochranes risk of bias 2.0 tool

Biomedicine & Pharmacotherapy, 169 , 115858

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Continue at the current dose until the tolerability window clears, then proceed