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Vitamin C is the most effective

Liu J-L

Among the tested interventions, Bifidobacterium infantis produced the most pronounced effects, showing the greatest reduction in gut-leakiness markers and the strongest upregulation of GABA-receptor expression (Zarezadeh et al., 2023)

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By inhibiting pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-), hesperidin mitigates vascular inflammation

This significantly increases liver sensitivity for growth hormone (LSG)