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2019;8:e1076

72 HP 130 IPAMORELIN Selective Ghrelin Receptor Agonist ALIASES Ipamorelin, NNC 26-0161, GHS-R1a agonist, selective ghrelin mimetic CLASS Synthetic pentapeptide selective ghrelin receptor agonist FORMULA C38H49N9O5 SEQUENCE Aib-His-D-2-Nal-D-Phe-Lys-NH2 HALF-LIFE ~2 hours ROUTES Subcutaneous (research) MECHANISM OF ACTION Pentapeptide selective agonist of the ghrelin receptor (GHS-R1a)

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Activation of SIRT increases resistance to OS (Haigis and Sinclair, 2010) through an increase in metabolic pathways responsible for the detoxification of ROS (Salvatori et al., 2017) such as superoxide dismutase 2 (SOD2), isocitrate dehydrogenase 2 (IDH2) and CAT (Tennen and Chua, 2011)