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observed a transient increase in IGF-1 expression at day 3 following vibration-induced Achilles tendon injury in rats ( In late-peak studies, In a rat supraspinatus tendon injury model induced by overloading, IGF-1 immunostaining was minimal at 4 and 8 weeks but markedly increased at 12 and 16 weeks ( In the single-time-point study, Tsubone et al

van Buul-Offers et al (1995) have shown that overexpression of IGF-2 in transgenic normal and pituitary deficient Snell dwarf mice causes increased growth of the thymus, suggesting a role for IGF-2 in thymic development by paracrine or autocrine mechanisms

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Interestingly, co-culturing IGF-I +/+ osteoclast precursors (spleen cells from WT mice), with IGF-I / osteoblasts (bone marrow stromal cells from IGF-I KO mice), produces significantly fewer (by 90%) multi-nucleated osteoclasts than coculturing IGF-I +/+ osteoclast precursors with IGF-I +/+ osteoblasts, suggesting that osteoblasts may be a source of IGF-I to promote osteoclastogenesis

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