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Rights and permissions Oncogenesis is an open-access journal published by Nature Publishing Group

[7] Another aspect is that MB, in high IV doses, can paradoxically cause methemoglobinemia because it can auto-oxidize at excessive concentrations

The anxiolytic mechanism appears to involve modulation of serotonergic neurotransmission, effects on GABA systems, and increased enkephalin levels through inhibition of enkephalinase enzymes

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Although neither the mechanism nor the implications of these changes are well defined, the high GSH content makes cancer cells chemoresistant, which is a major factor that limits drug treatment