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A prospective, randomized, controlled proof-of-concept study in bowel resection patients investigated ipamorelin 0.03 mg/kg administered twice daily for up to 7 days

Quick Answer: Tirzepatide modulates rather than eliminates hunger, and persistent appetite can result from insufficient dosage, early treatment phase, individual response variability, lifestyle factors, or normal physiological needs

Gafvelin and E.S.J

J Transl Med 11, 74, doi: 10.1186/147958761174 (2013)

Provides sustained anabolic signaling environment: Repeated stimulation of GH pulses increases cumulative exposure to downstream anabolic pathways

And having people be healthier in terms of their eating, and it's not, you know, heavy people aren't at fault, right