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Patients with well-managed hypothyroidism on stable levothyroxine replacement can generally proceed with GLP-1 therapy if clinically indicated
Final thoughts Tesofensine represents a powerful weight loss compound with proven 10-12% average weight loss through triple monoamine reuptake inhibition targeting dopamine, norepinephrine, and serotonin
GLP-1 GLP-1 receptor antagonist medications (semaglutides) are primarily known as a weight loss medication that was developed to help obese individuals get within a healthy body mass index (BMI)
These studies consistently demonstrate measurable reductions in fine wrinkles, improvement in mottled hyperpigmentation, increased dermal collagen (confirmed on biopsy), and smoother skin texture over 24 to 48 weeks of use
Because GLP1 and amylin signaling can slow gastric emptying, some people feel full sooner and for longer after meals