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Efficacy and safety of sitagliptin monotherapy in Japanese patients with type 2 diabetes

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The final study population included 174,678 individuals with T1D, contributing 6,092,537 person-trials across the 135 trials (Extended Data Fig

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Dual-agonist compounds such as Tirzepatide add GIP receptor activity on top of the GLP-1 pathway, producing a more pronounced metabolic effect than single-agonist compounds but still without the glucagon-receptor-driven energy expenditure component unique to triple agonists