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In the previously discussed KC model, exenatide treatment increased ductal cell proliferation as compared to control mice 18

Weve seen that 15 to 20% of our patients on GLP-1s are on low doses that would be considered microdoses six months into therapy, which either shows us that their progression is being limited by side effects because they probably dont have additional options to reduce or slow their dosing or theyre already getting to their weight loss goal at those lower doses

However, when the assay was repeated with 5-amino-6-fluoro-1MQ, an analogue of 5-amino-1MQ that did not interfere with the NAMPT assay, no inhibition of NAMPT was observed with analogue concentrations between 30 and 600 M (data not shown)

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