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Specifically, ATF-4 enhances stress resistance and promotes longevity in worms by upregulating the transsulfuration enzyme CTH-2, increasing hydrogen sulfide (H 2 S) production (Statzer et al., 2022)

The ability of your liver to produce glutathione will continue to decrease as you age

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Preclinical studies have consistently shown that targeting ferroptosis with drugs such as iron chelators, lipid peroxidation inhibitors or NRF2 activators can produce significant neuroprotective effects