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This story is part of Project Remission, a digital series from the American College of Lifestyle Medicine produced in partnership with Content With Purpose

But losing weight quickly can sometimes cause side effects you might not expect, like missing out on important nutrients such as protein, calcium, and vitamin D, changes in hormones that keep your bones strong, and even bone loss that happens faster than your body can rebuild

So the same pharmaceutical company makes a pure insulin product (Toujeo), a combination insulin-plus-GLP-1 product (Soliqua), and markets them through similar channels to similar patient populations

The World Health Organization's December 2025 guidelines emphasized the importance of resistance training to protect muscle mass during GLP-1 therapy, acknowledging this as a limitation of current treatment approaches [49]

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Dosing Methyl B12 B12 is a water soluble vitamin, meaning the body uses what it needs and then excretes excess in the urine