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The analysis of pharmacovigilance for a drug, utilizing postmarketing safety databases like the FAERS, plays a crucial role in the ongoing management of risks by detecting safety signals that may not have been identified during the drugs clinical development phase [Reference Anand, Ensor, Trachtenberg and Bernicker10, Reference Jedlowski, Jedlowski and Fazel14, Reference Egeberg and Thyssen32Reference Yu, Krantz, Phillips and Stone35]

The audit trail is the tool used to verify the accuracy of the input (the method parameters) and the output (the integration results)

Eu J Pharmacol 2007

Notably, alterations in cholinergic signaling, neuroinflammation involving microglial activation, and calcium dysregulation have emerged as relevant contributors to AD pathogenesis

Garigliany MMO, Desmecht DJ

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