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Although it is relatively weak in terms of reactivity, it can undergo dismutation, either spontaneously or catalyzed by the enzyme superoxide dismutase (SOD), to form hydrogen peroxide (H2O2) [2, 26]

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Additionally, numerous pro-inflammatory changes have been observed in the lungs of smokers, with inflammation closely linked to tumor promotion and the activation of factors like NFB [136,137,138]

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TABLE 1 Summary of FDA-approved iron chelators