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In the phase 3 combination with semaglutide, gastrointestinal events were reported in 79.6 percent of the CagriSema group, compared with 39.9 percent on placebo NEJM, 2025

The lack of Intrinsic Factor is caused by Atrophic Gastritis which is when the stomach lining has been inflamed for years

A.MnatsakanyanN.NiuY.LicznerskiP.WuJ.et al (2019)

Long-term human data beyond 6 months remains limited, but preclinical toxicology studies in animals showed no concerning findings with chronic administration

Retrieved June 8, 2025, from Holick, M