Putative mechanisms of tirzepatide-mediated nephroprotection The pathogenesis of CKD in patients with T2D likely involves other potential contributors besides hyperglycemia, such as hypertension, dyslipidemia, obesity, insulin resistance, glomerular atherosclerosis, renal ischemia, and nephron aging [53]
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Takeaway: key safety considerations for metformin While metformin is generally safe, it may cause certain side effects, such as diarrhea, nausea, or gas