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Research published in the British Medical Journal (BMJ) found that while GLP-1s produce substantial initial weight loss, many people regain weight after discontinuing treatment
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26 Spironolactone is readily available for compounding, and multiple clinical studies to date have evaluated a range of topical spironolactone formulations and concentrations including 5% cream, 5% gel, 2% solution, 3% powder, and 1% nanogel
The most common are nausea, constipation, and fatigue in the early weeks, usually while your dose is still increasing