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The medications themselves do not directly cause muscle loss the mechanism is indirect: appetite suppression reduces overall food intake, which lowers protein consumption, at the same time that caloric restriction elevates whole-body EAA requirements

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Observational studies and clinical trials have further supported the role of GLP-1RAs in AD management

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Semaglutide is given as an injection, which means it is administered using a small needle that delivers the medication under the skin