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However, it is well established that enteroendocrine cells form direct, physical contacts with extrinsic enteric-associated neurons (both the sensory afferents and autonomic efferents) which innervate the gut and directly link the gut to the brain via the vagus nerve ( 3-mRNA sequencing reveals that GLUTag cells appear to be a good model to investigate the function of NMDA receptors in human gut endocrine cells

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2023;43:12981306 Chen F, Shi Y, Liu X, Lei L, Xu J

Yes, when administered by trained medical professionals