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Interestingly, some observational studies suggest that metformin may have chemo-preventative properties against colorectal malignancy (84)

10.1038/s41574-023-00821-8 3 BeccutiG.BiolettoF.Parasiliti-CaprinoM.BensoA.GhigoE.CicolinA.et al (2024)

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In vivo and in vitro analyses revealed that these metabolites drive oncogenic metabolic reprogramming via upregulated CPT1A expression, thereby accelerating CRC progression

The impact of demethylation of D-loop region of mtDNA on mtDNA copy number, cell cycle progression, apoptosis, and cell proliferation in CRC remains uncertain (212)

To clarify, this means Dihexa is not merely seven times more effective, but 10 million times more potent than BDNF in promoting neuronal growth