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Similar phenotypes were also observed when GCLC was deleted in HCC-1806 cells (a human breast cancer cell line), which showed complete depletion of GSH levels (Fig

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While ferroptosis has been linked to AKI, diabetic nephropathy (DN), and renal fibrosis, existing reviews largely suffer from two limitations: they either focus on single kidney disease entities (e.g., only AKI or DN) or reiterate generic ferroptosis mechanisms, lacking a unified pathophysiological framework that bridges acute insults, chronic fibrosis, and even renal carcinogenesis

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