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They expand access and reduce inequity
A prospective randomized controlled study evaluating the potential preventive effect of L-carnosine on acute oxaliplatin neurotoxicity in patients with colorectal cancer enrolled 65 patients and showed that the levels or activities of NFB (27%) and TNF- (36.6%) were significantly decreased in the group receiving the FOLFOX-6 regimen (oxaliplatin, 5FU, and leucovorin) with daily oral L-carnosine (500 mg), while L-carnosine as a supplement for patients with CIPN alleviated neuropathic symptoms by decreasing oxidative stress (Nrf-2 and NF-B pathways) and apoptosis (caspase-3 activity) [144]
Medical records must be submitted demonstrating clinical improvement, including a decrease in the member's EDS
If peak concentration drives the worst of the nausea, and split dosing lowers the peak by 20%, then a meaningful reduction in nausea intensity is pharmacologically plausible
JAMA Psychiatry 78 , 151160 (2021)
If your insurance excludes obesity medications entirely, manufacturer programs wont help
