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For darker skin tones and for melasma, the safer path is usually a device like Pico laser used at conservative settings, or a non-laser route such as microneedling with PDRN and skin-type-compatible peels, rather than aggressive IPL

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One study found a SNP (rs2232165) in exon 1 of the GHS-R1A gene to be linked with heavy alcohol use (Landgren et al., 2008)