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When evaluating the differences in the construction of the NALFD/NASH model between the two methods, it was found that the MCD diet could spontaneously lead to liver fibrosis within 24 weeks and significantly affect the expression of genes involved in liver fibrosis pathways
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Mietlicki-Baase EG, Ortinski PI, Rupprecht LE, Olivos DR, Alhadeff AL, Pierce RC, et al
The postulated mechanism by which metformin acts as a weight-reducing agent is reducing food intake and increasing insulin sensitivity through tissue-specific AMPK action
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