Clinical signs of Thiamine deficiency include fatigue, muscle weakness, loss of appetite and increased heart rate
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In both in vitro and in vivo rodent studies, BPC-157 induces early expression of EGR-1 and its corepressor NAB2, forming a regulatory feedback loop that modulates the duration and amplitude of angiogenic gene transcription during wound healing, which suggests BPC-157 may engage feedback mechanisms to prevent excessive angiogenic signaling [56]
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